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Preclinical Imaging Molecular medicine – as a developing independent Academic subject – has become positively interdisciplinary, attracting professionals from places widely distinctive as cardiology, oncology, immunology, neurology, biology, chemistry, genetics, genomics, nuclear medicine, radiology and pharmacology. By attaching a tag Imaging is performed Or label to the molecule of interest, which can be detected by the emission of light when excited. Molecular imaging aims to show the source of disease carriers through the combined use of molecular bio-markers and probes, using a vast variety of preclinical imaging methods. Molecular Imaging is the visualization of Molecules or events using probes that are highly targeted. It’s used to offer characterization and measurement of biological processes in living animals and humans (in vivo). Molecular imaging is a growing research discipline of Non-invasive, diagnostic imaging technologies which may create images of both functional and bodily facets of the body. MI is directed at testing and developing novel techniques specific molecular pathways in vivo, especially the ones that are targets in disease processes. As opposed to other conventional imaging techniques (like Microscopy), this imaging technique produces images on tissues within a living organism. Molecular imaging primarily provides information about biological processes (function) while other imaging techniques like CT, X-rays, MRI and ultrasound, capture the phenotypic changes in the gross anatomic level that result from molecular processes.
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During the past few decades magnetic resonance imaging (MRI) – especially, preclinical MRI – and magnetic resonance spectroscopy (MRS), have proven themselves to be extremely useful for research applications from the various Life Sciences. Research is heavily reliant on animal MRI which Has, in many instances, become recognized as the benchmark for this field. Some of the programs of clinical and preclinical MRI include research regarding arthritis, oncology and metabolic disorders; as well as respiratory, gastro-intestinal and cardiovascular studies. Recent developments in molecular biology and genome research have resulted in increased use of MRI applications in animals. Rapid phenotyping of transgenic animals and imaging are but two applications which have extended preclinical MRI’s role .
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The assortment of MRI applications includes brain and Organ imaging, tumor assessment, disease imaging. Possible research applications include analysis of protein interactions, investigation of agents and new contrast mechanisms, monitoring gene expression, and determination of pharmacokinetics. Although small animal scanners are superior to clinical Scanners concerning providing a far better signal-to-noise ratio, the available pulse sequences are not the same as those in clinical scanners, and the magnetic field strength is higher. Molecular imaging aims to reveal the source of disease Carriers through the combined use of probes and bio-markers, using a variety of preclinical imaging techniques. MR imaging has two advantages over other imaging techniques: higher spatial resolution (micrometer rather than several millimeters) and the fact that physiologic and anatomic information can be extracted simultaneously.